Hyperprolactinoma

Hyperprolactinoma is a benign tumor type of pituitary adenoma causes excessive production of prolactin hormone

Prolactin hormone functions

• lactation – milk production
• Breast development
• Reproductive function regulation
  Prolactin inhibits GnRH (Gnadotropin releasing hormone) leading to suppression of ovulation
• Immune system modulation
• Metabolism

Etiology

• tumurs – prolactin secreting adenoma(macro adenoma,micro adenoma)
• dopamine disruption – normally dopamine inhibits prolactin-                                  medication interference with dopamine.
  Antipsychotics- respiridone ,haloperidol.
  Antidepressants- tricyclics
  CCB- verapamil
• Primary hypothyroidsm
• Spinal cord lesions
• pregnancy and lactation
• Stress and sleep

Clinical manifestations

• In women’s
  Galactorrhea
  Infertility
  Loss of Libido
  Amenorrhea
• In men
  Erectile dysfunction
  Gynaecomastia
  Infertility
• others – Headache and vision problem

Diagnosis

• increased prolactin level ( >200 )
• MRI

Management of Hyperprolactinoma

Symptomatic
Dopamine receptors agonist – carbergoline, bromocriptin

if medical management fails

• Trans sphenoidal surgery
• pitutory radiotherapy